The Coalition collaborates with leading multi-lateral institutions and private sector alliances. These regional and global partnerships with inter-governmental and multi-stakeholder organizations propel access to life-saving and life-improving products as well as ensure consistent dialogue on common challenges. At the global level, the Coalition engages with the World Health Organization (WHO)World Trade Organization (WTO), the Organization for Economic Co-opera­tion and Development (OECD), the Global Medical Technology Alliance (GMTA), and the Global Diagnostics Alliance (GDA). Within Latin America, the Coalition participates in the Summit of the Americas and CEO Summit of the Americas, led by the Organization of American States (OAS), and as a member of the Americas Business Dialogue (ABD), led by the Inter-American Development Bank (IDB).

The Coalition also partners with the Pacific Alliance, a regional integration initiative that counts Chile, Colombia, Mexico, and Peru as principal members. The Coalition coordinates its activities with the Asia-Pacific Economic Cooperation forum (APEC) which includes 21 Pacific Rim member economies, including Canada, Chile, Mexico, Peru, and the United States from the Americas. The Coalition, its member associations and their member companies engage with these institutions and alliances on a number of issues, including good regulatory practices, medical device regulatory convergence, trade, pandemic response, health policy, and ethical business conduct, among others.